Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ACACB | O00763 | 2/20 | 0.53 |
| ▸ | ACACA | Q13085 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31579588 | 0.93 | ACACB (0.54) | ALDH1A1MAPK1HPGDSMN1; SMN2ACACB | |
| SCHEMBL3598733 | 0.85 | KMT2A (0.69) | ALDH1A1KMT2APTGS1MMP8 | |
| SCHEMBL5924513 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPK1HPGDSMN1; SMN2ACACB | |
| SCHEMBL6444084 | 0.84 | MEN1 (0.49) | ALDH1A1HPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL1565875 | 0.83 | MAPK1 (0.51) | ALDH1A1MAPK1HPGDSMN1; SMN2ACACB | |
| SCHEMBL3613402 | 0.83 | MAPK1 (0.51) | ALDH1A1MAPK1HPGDSMN1; SMN2ACACB | |
| Ammonia Solution, Strong SCHEMBL27830689 | 0.83 | KMT2A (0.67) | ALDH1A1KMT2APTGS1MMP8 | |
| SCHEMBL29002097 | 0.82 | KMT2A (0.56) | ALDH1A1HPGDKMT2APTGS1MMP8 | |
| SCHEMBL11563916 | 0.81 | MAPK1 (0.50) | ALDH1A1MAPK1HPGDSMN1; SMN2ACACB | |
| SCHEMBL28980706 | 0.81 | MAPK1 (0.50) | ALDH1A1MAPK1HPGDSMN1; SMN2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153015-B1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| CN-1147481-C | Pyrimidine-2,4,6-triones as inhibitors of matrix metalloproteinases | - | 2004-04-28 | — | — | CN | disclosed |
| CN-1339028-A | Pyrimidine-2,4,6-triones as inhibitors of matrix metalloproteinases | HOFFMANN LA ROCHE (CH) | 2002-03-06 | — | — | CN | disclosed |
| EP-1153015-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-6265578-B1 | MATRIX METALLOPROTEASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000047565-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-17 | — | — | WO | disclosed |