Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6813838 | 0.88 | LTA4H (0.50) | HDAC3LTA4HPPARACETPFAAH | |
| SCHEMBL6813620 | 0.85 | HPGD (0.46) | HDAC3LTA4HPPARAHPGDSMN1; SMN2 | |
| SCHEMBL10943740 | 0.82 | KCNN4 (0.46) | NAAAPOLBATML3MBTL1ALDH1A1 | |
| SCHEMBL10947074 | 0.82 | KCNN4 (0.46) | NAAAPOLBATML3MBTL1ALDH1A1 | |
| SCHEMBL10946564 | 0.82 | KCNN4 (0.46) | NAAAPOLBATML3MBTL1ALDH1A1 | |
| SCHEMBL6552542 | 0.81 | SCN5A (0.46) | NAAAPOLBALDH1A1GAAMAPT | |
| SCHEMBL10945058 | 0.80 | SRC (0.48) | NAAAPOLBALDH1A1GAA | |
| SCHEMBL28003859 | 0.79 | ZDHHC2 (0.44) | FAAHGAA | |
| SCHEMBL28080179 | 0.77 | KCNN4 (0.50) | RAB9APOLBL3MBTL1ALDH1A1GAA | |
| SCHEMBL16732175 | 0.77 | KCNN4 (0.56) | RAB9APOLBL3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153015-B1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| EP-1153015-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-6265578-B1 | MATRIX METALLOPROTEASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000047565-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-17 | — | — | WO | disclosed |