Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818662 | 0.85 | HDAC3 (0.49) | HPGDSMN1; SMN2PPARANPC1ALDH1A1 | |
| SCHEMBL6810349 | 0.81 | SMN1; SMN2 (0.46) | HPGDSMN1; SMN2KCNN4NPC1ALDH1A1 | |
| SCHEMBL6810533 | 0.79 | PTPRB (0.44) | HPGDSMN1; SMN2KCNN4NPC1MAPK14 | |
| SCHEMBL3191632 | 0.78 | SMN1; SMN2 (0.51) | HPGDSMN1; SMN2KCNN4PPARANPC1 | |
| SCHEMBL7759944 | 0.76 | SMN1; SMN2 (0.50) | HPGDSMN1; SMN2KCNN4PPARANPC1 | |
| SCHEMBL9475849 | 0.76 | CES1 (0.53) | HPGDSMN1; SMN2KCNN4NPC1ALDH1A1 | |
| SCHEMBL16732175 | 0.76 | KCNN4 (0.56) | KCNN4ALDH1A1LMNAPOLBHTT | |
| SCHEMBL9475853 | 0.75 | NPC1 (0.48) | HPGDSMN1; SMN2KCNN4NPC1ALDH1A1 | |
| SCHEMBL11508443 | 0.74 | LTA4H (0.47) | PPARANPC1ALDH1A1LMNAPOLB | |
| SCHEMBL16732223 | 0.72 | KCNN4 (0.51) | HPGDSMN1; SMN2KCNN4NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153015-B1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| CN-1147481-C | Pyrimidine-2,4,6-triones as inhibitors of matrix metalloproteinases | - | 2004-04-28 | — | — | CN | disclosed |
| CN-1339028-A | Pyrimidine-2,4,6-triones as inhibitors of matrix metalloproteinases | HOFFMANN LA ROCHE (CH) | 2002-03-06 | — | — | CN | disclosed |
| EP-1153015-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-6265578-B1 | MATRIX METALLOPROTEASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000047565-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-17 | — | — | WO | disclosed |