Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822135 | 0.96 | CRHR1 (0.42) | CRHR1PIK3CA | |
| SCHEMBL6818621 | 0.87 | PIK3CA (0.37) | CRHR1PIK3CA | |
| SCHEMBL6817739 | 0.83 | CYP1A2 (0.43) | — | |
| SCHEMBL6814074 | 0.83 | ERBB2 (0.47) | CRHR1 | |
| SCHEMBL6821866 | 0.82 | CRHR1 (0.39) | CRHR1PIK3CA | |
| SCHEMBL6819175 | 0.82 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL6818951 | 0.82 | — | — | |
| SCHEMBL6818754 | 0.80 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL6082194 | 0.80 | — | — | |
| SCHEMBL6082186 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | claimed |
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |