Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.58 |
| ▸ | MMP13 | P45452 | 19/20 | 0.58 |
| ▸ | MMP9 | P14780 | 17/20 | 0.58 |
| ▸ | MMP1 | P03956 | 12/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811146 | 0.92 | ADAM17 (0.57) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6815417 | 0.92 | ADAM17 (0.59) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL3945004 | 0.91 | ADAM17 (0.68) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6815491 | 0.91 | MMP13 (0.53) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6816580 | 0.90 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6810712 | 0.89 | ADAM17 (0.61) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6816630 | 0.88 | ADAM17 (0.50) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6814713 | 0.88 | ADAM17 (0.52) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6815416 | 0.87 | ADAM17 (0.53) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6815806 | 0.85 | MMP13 (0.55) | ADAM17MMP13MMP9MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144369-B1 | ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| US-6277885-B1 | INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY | 2001-08-21 | — | — | US | disclosed |