Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13081161 | 1.00 | MAPT (0.65) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL31484585 | 1.00 | MAPT (0.65) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL6819211 | 1.00 | MAPT (0.65) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL4232054 | 0.83 | MAPT (0.53) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL2317657 | 0.82 | MAPT (0.62) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL28569469 | 0.82 | MAPT (0.51) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL4353983 | 0.80 | MAPT (0.61) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL4353987 | 0.80 | MAPT (0.61) | MAPTKDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL9316913 | 0.78 | MAPT (0.58) | MAPTKDM4ESMN1; SMN2GAATP53 | |
| SCHEMBL31507613 | 0.78 | ALDH1A1 (0.44) | MAPTKDM4EHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580416-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160002225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | SCHRODINGER, LLC | 2016-01-07 | — | — | US | disclosed |
| WO-2004067518-A1 | SUBSTITUTED PYRIMIDINES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2004-08-12 | — | — | WO | disclosed |
| EP-0584988-B1 | Process for the preparation of salicylaldoxine derivatives | ZENECA LTD (GB) | 1996-10-23 | — | — | EP | disclosed |
| US-5502254-A | Method for the preparation of 2-hydroxyarylaldoximes | ZENECA LIMITED (GB) | 1996-03-26 | — | — | US | disclosed |
| US-5399761-A | Method for the preparation of 2-hydroxyarylaldoximes | ZENECA LIMITED (GB) | 1995-03-21 | — | — | US | disclosed |
| EP-0584988-A1 | Process for the preparation of salicylaldoxine derivatives | ZENECA LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |
| US-5250486-A | Catalyst comprising a manganese compound, a chelate compound, a base and an unsaturated ketone or ether; controlled molecular weight; odorless; stabile thermal properties when blended with styrene resins | GENERAL ELECTRIC COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0491190-A2 | Polyphenylene ether process and resin composition | GENERAL ELECTRIC COMPANY (US) | 1992-06-24 | — | — | EP | disclosed |
| US-5037943-A | Oxidative coupling using alkaline catalysts system of manganese chelate and unsaturated or diketune or vinyl ether | GENERAL ELECTRIC CO. (US) | 1991-08-06 | — | — | US | disclosed |
| US-3972851-A | Preparation of polyphenylene oxide using a manganese(II) ortho-hydroxyarene-oxime chelate reaction promoter | GENERAL ELECTRIC COMPANY (US) | 1976-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | MAPT 4186/4885KDM4E 1328/4885HTT 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.