Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819403 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6822787 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6822578 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6822745 | 0.78 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6822624 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6822981 | 0.76 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL10483795 | 0.73 | ALDH1A1 (0.60) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6822575 | 0.73 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL13183860 | 0.72 | TSHR (0.54) | KDM4EMAPK1KMT2AMEN1L3MBTL1 | |
| SCHEMBL6819322 | 0.72 | CYP3A4 (0.54) | ALDH1A1KDM4EMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812825-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-02-11 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0812825-A1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-17 | — | — | EP | disclosed |