Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822578 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL6822981 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL2127920 | 0.80 | KMT2A (0.66) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL6822575 | 0.79 | ALDH1A1 (0.53) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL2336216 | 0.79 | CYP1A2 (0.55) | ALDH1A1KMT2AKDM4EMEN1GAA | |
| SCHEMBL6822746 | 0.78 | MAPK1 (0.56) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL6819306 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL6819322 | 0.78 | CYP3A4 (0.54) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL9828028 | 0.77 | MEN1 (0.62) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL7046987 | 0.77 | ALDH1A1 (0.72) | ALDH1A1KMT2AKDM4EMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812825-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-02-11 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0812825-A1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-17 | — | — | EP | disclosed |