Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.46 |
| ▸ | PDE4A | P27815 | 10/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823038 | 0.83 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL7366790 | 0.83 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL6820516 | 0.83 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL5758837 | 0.75 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7294542 | 0.72 | MAPT (0.66) | CHEK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL31525472 | 0.72 | HTT (0.53) | CHEK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL8688863 | 0.71 | LMNA (0.51) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL5823060 | 0.69 | PDE4A (0.77) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8477546 | 0.68 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL24196349 | 0.68 | MAPT (0.56) | CHEK1MAPTSMN1; SMN2KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037784-A2 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | IRM LLC (BM) | 2004-05-06 | — | — | WO | disclosed |