Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.55 |
| ▸ | PDE4A | P27815 | 8/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294542 | 0.87 | MAPT (0.66) | MAPTSMN1; SMN2 | |
| SCHEMBL8688863 | 0.86 | LMNA (0.51) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL6823038 | 0.84 | PDE4A (0.47) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL6820516 | 0.83 | PDE4B (0.48) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL6820741 | 0.83 | PDE4B (0.46) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL5758837 | 0.81 | PDE4A (0.53) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7806296 | 0.80 | MAPT (0.54) | MAPTSMN1; SMN2 | |
| SCHEMBL24196349 | 0.79 | MAPT (0.56) | MAPTSMN1; SMN2 | |
| SCHEMBL20091850 | 0.79 | CHEK1 (0.60) | MAPTSMN1; SMN2 | |
| SCHEMBL20180887 | 0.79 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1604776-A | 4-4-alkoxy-3-hydroxyphenyl-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes | MEMORY PHARM CORP (US) | 2005-04-06 | — | — | CN | claimed |
| US-5728705-A | Method of inducing vasorelaxation to treat pulmonary hypertension | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1998-03-17 | — | — | US | claimed |
| WO-2015068142-A2 | COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS, USES AND METHOD OF MANAGEMENT OF MYELOPROLIFERATIVE DISORDER | CELLWORKS GROUP, INC. (US) | 2015-05-14 | — | — | WO | disclosed |
| CN-1604776-A | 4-4-alkoxy-3-hydroxyphenyl-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes | MEMORY PHARM CORP (US) | 2005-04-06 | — | — | CN | disclosed |
| WO-2000072799-A2 | METHOD AND COMPOSITIONS FOR TREATING THE INFLAMMATORY RESPONSE | THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2000-12-07 | — | — | WO | disclosed |
| US-5891904-A | Use of inhibitors of phosphodiesterase IV | Forssmann, Wolf-Georg (DE) | 1999-04-06 | — | — | US | disclosed |
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| US-5712282-A | PHOSPHODIESTERASE INHIBITORS | Iyo, Masaomi (JP) | 1998-01-27 | — | — | US | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |
| EP-0584208-A4 | — | — | 1994-03-23 | — | — | EP | disclosed |
| EP-0584208-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992019594-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-11-12 | — | — | WO | disclosed |