SCHEMBL6821029

SCHEMBL6821029

O=C(O)Cc1ccc2oc(-c3ccc(NC(=O)C=Cc4ccc(Br)cc4)c(F)c3)nc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HPSE Q9Y251 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20280936 1.00 HPSE (1.00) HPSE
SCHEMBL29424176 1.00 HPSE (1.00) HPSE
SCHEMBL6821869 0.94 HPSE (0.89) HPSE
SCHEMBL6821844 0.92 HPSE (1.00) HPSE
SCHEMBL6822223 0.90 HPSE (0.90) HPSE
SCHEMBL6822193 0.90 HPSE (1.00) HPSE
SCHEMBL6822288 0.89 HPSE (1.00) HPSE
SCHEMBL6824237 0.89 HPSE (1.00) HPSE
SCHEMBL7118415 0.89 HPSE (0.87) HPSE
SCHEMBL6818350 0.88 HPSE (0.83) HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4518857-A1 METHODS OF TREATING ALLOGRAFT REJECTION Bargent Therapeutics Pty Limited (AU) 2025-03-12 EP disclosed
WO-2023212768-A1 METHODS OF TREATING ALLOGRAFT REJECTION Bargent Therapeutics Pty Limited (AU) 2023-11-09 WO disclosed
US-20200093852-A1 Methods of Treating Ocular Disorders Beta Therapeutics Pty Ltd (AU) 2020-03-26 US disclosed
EP-3554505-A1 METHODS OF TREATING OCULAR DISORDERS Beta Therapeutics Pty. Ltd. (AU) 2019-10-23 EP disclosed
EP-3104873-B1 FGF-8 FOR USE IN TREATING DISEASES OR DISORDERS OF ENERGY HOMEOSTASIS UNIV MUENCHEN TECH (DE) 2019-09-04 EP disclosed
WO-2018107226-A1 METHODS OF TREATING OCULAR DISORDERS Beta Therapeutics Pty. Ltd. (AU) 2018-06-21 WO disclosed
US-20160168567-A1 UNA SINGLE STRANDED OLIGOMERS FOR THERAPEUTICS MARINA BIOTECH, INC. 2016-06-16 US disclosed
WO-2004046122-A2 BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES AND THEIR USE AS HEPARANASE INHIBITORS OXFORD GLYCOSCIENCES (UK) LTD (GB) 2004-06-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200093852-A1 Methods of Treating Ocular Disorders ALDH1A2, HPSE, RB1 HPSE 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.