Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 13/20 | 0.62 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301990 | 0.85 | CDK2 (0.62) | CDK1CDK2CDK9CCNA2CCNA1 | |
| SCHEMBL17639874 | 0.83 | YTHDC1 (0.61) | CDK1CDK2ADORA3ADORA1ADORA2A | |
| SCHEMBL24966176 | 0.83 | CDK1 (0.69) | CDK1CDK2ADORA3ADORA1CCNA2 | |
| SCHEMBL13057362 | 0.81 | CDK2 (0.60) | CDK1CDK2CDK9ADORA3ADORA1 | |
| SCHEMBL27870417 | 0.80 | CDK2 (0.56) | CDK1CDK2CDK9CCNA2CCNA1 | |
| SCHEMBL6821043 | 0.79 | CDK2 (0.62) | CDK1CDK2CDK9ADORA3ADORA1 | |
| SCHEMBL13057358 | 0.79 | CDK2 (0.61) | CDK1CDK2CDK9ADORA3ADORA1 | |
| SCHEMBL6817833 | 0.79 | CDK1 (0.63) | CDK1CDK2CCNA2CCNA1CDK5 | |
| SCHEMBL22131204 | 0.78 | CDK5 (0.65) | CDK1CDK2CCNA2CCNA1CDK5 | |
| SCHEMBL6821032 | 0.78 | ADORA3 (0.64) | CDK1CDK2ADORA3ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752629-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190084984-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-03-21 | — | — | US | disclosed |
| US-10174031-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180009810-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-01-11 | — | — | US | disclosed |
| US-9796714-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-10-24 | — | — | US | disclosed |
| US-9796714-B2 | Calcium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-10-24 | — | — | US | disclosed |
| US-20160090387-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-31 | — | — | US | disclosed |
| US-20160090387-A1 | CALCIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-31 | — | — | US | disclosed |
| EP-1056745-B1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMA INC (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6413974-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES, PARTICULARLY CDK-2; PREVENTING APOPTOSIS IN NEURONAL CELLS; ANTINEOPLASTIC AGENTS; NEURONAL INJURY AND DEGENERATION; CEREBROVASCULAR DISEASE | AVENTIS PHARMACEUTICALS INC. | 2002-07-02 | — | — | US | disclosed |
| EP-1056745-A2 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043676-A2 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009810-A1 | CALCIUM CHANNEL AGONISTS | CACNA1E, CACNA1C, CACNA1S | CDK1 2530/4885CDK2 3024/4885CDK9 3834/4885 |
| US-20190084984-A1 | CALCIUM CHANNEL AGONISTS | CACNA1E, CACNA1C, CACNA1S | CDK1 2530/4885CDK2 3024/4885CDK9 3834/4885 |
| US-20160090387-A1 | CALCIUM CHANNEL AGONISTS | CACNA1E, CACNA1C, CACNA1S | CDK1 2530/4885CDK2 3024/4885CDK9 3834/4885 |
| US-10174031-B2 | Calcium channel agonists | CACNA1E, CACNA1C, CACNA1S | CDK1 2530/4885CDK2 3024/4885CDK9 3834/4885 |
| US-10752629-B2 | Calcium channel agonists | CACNA1E, CACNA1C, CACNA1S | CDK1 2530/4885CDK2 3024/4885CDK9 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.