Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 9/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19763769 | 0.90 | YTHDC1 (0.54) | YTHDC1CTSLCDK1CCNA2CDK2 | |
| SCHEMBL17628575 | 0.84 | YTHDC1 (0.53) | YTHDC1CTSLCDK1CCNA2CDK2 | |
| SCHEMBL17628619 | 0.81 | YTHDC1 (0.57) | YTHDC1CDK1CCNA2CDK2CCNA1 | |
| SCHEMBL6817859 | 0.79 | CDK1 (0.74) | YTHDC1CTSLCDK1CCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL6822218 | 0.78 | CCNE1 (0.64) | CDK1CCNA2CDK2CCNA1 | |
| SCHEMBL17628580 | 0.77 | TMIGD3 (0.70) | YTHDC1CTSLCDK1CCNA2CDK2 | |
| SCHEMBL17628578 | 0.76 | CDK1 (0.65) | YTHDC1CTSLCDK1CCNA2CDK2 | |
| SCHEMBL17639877 | 0.73 | CDK1 (0.62) | YTHDC1CDK1CCNA2CDK2CCNA1 | |
| SCHEMBL6817839 | 0.73 | HDAC1 (0.67) | YTHDC1CTSLTMIGD3ADORA2AADORA1 | |
| SCHEMBL24422306 | 0.72 | CTSL (0.52) | YTHDC1CTSLCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056745-B1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMA INC (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6413974-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES, PARTICULARLY CDK-2; PREVENTING APOPTOSIS IN NEURONAL CELLS; ANTINEOPLASTIC AGENTS; NEURONAL INJURY AND DEGENERATION; CEREBROVASCULAR DISEASE | AVENTIS PHARMACEUTICALS INC. | 2002-07-02 | — | — | US | disclosed |
| EP-1056745-A2 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043676-A2 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |