Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818220 | 0.92 | NPC1 (0.52) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6822403 | 0.84 | NPC1 (0.48) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6821903 | 0.80 | NPC1 (0.53) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6821078 | 0.80 | NPC1 (0.52) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6821886 | 0.76 | NPC1 (0.62) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6822211 | 0.76 | HPSE (0.61) | MAPTALDH1A1NPC1MAPK1KDM4E | |
| SCHEMBL6818596 | 0.76 | MAPT (0.56) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6821840 | 0.74 | NPC1 (0.65) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14592383 | 0.73 | ESR1 (0.58) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6821264 | 0.73 | HPSE (0.73) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004046122-A2 | BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES AND THEIR USE AS HEPARANASE INHIBITORS | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-06-03 | — | — | WO | disclosed |