SCHEMBL6821311

CN1CC[C@@H](Oc2cc(NS(=O)(=O)c3ccc(Sc4ccc(C(F)(F)F)cc4)c(Cl)c3)ccc2C(F)(F)F)C1.COc1cccc(Sc2ccc(S(=O)(=O)Nc3ccc(C(F)(F)F)c(O[C@@H]4CCN(C)C4)c3)cc2Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	UTS2R	Q9UKP6	16/20	0.54

▸	KDM4E	B2RXH2	1/20	0.40

▸	ALDH1A1	P00352	1/20	0.40

▸	MAPT	P10636	1/20	0.40

▸	SMN1; SMN2	Q16637	1/20	0.40

▸	SCN1A	P35498	1/20	0.39

▸	SCN8A	Q9UQD0	1/20	0.39

▸	MEN1	O00255	1/20	0.37

▸	ALOX15	P16050	1/20	0.37

▸	MAPK1	P28482	1/20	0.37

▸	KMT2A	Q03164	1/20	0.37

▸	RORA	P35398	1/20	0.36

▸	RORC	P51449	1/20	0.36

▸	NR1H2	P55055	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6820351	0.92	UTS2R (0.57)	UTS2RKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL6820339	0.92	UTS2R (0.57)	UTS2RKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL6820300	0.89	UTS2R (0.62)	UTS2R
SCHEMBL6820293	0.89	UTS2R (0.62)	UTS2R
SCHEMBL6824468	0.85	UTS2R (0.64)	UTS2R
SCHEMBL6824460	0.85	UTS2R (0.64)	UTS2R
SCHEMBL8342831	0.84	UTS2R (0.57)	UTS2RKDM4EMAPTSCN1ASCN8A
SCHEMBL6820790	0.84	UTS2R (0.57)	UTS2RKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL6820792	0.84	UTS2R (0.57)	UTS2RKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL6820307	0.84	UTS2R (0.59)	UTS2RKDM4EALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2004043917-A1	SULFONAMIDES	SMITHKLINE BEECHAM CORPORATION (US)	2004-05-27	—	—	WO	disclosed