SCHEMBL6820293

SCHEMBL6820293

COc1cccc(Sc2ccc(S(=O)(=O)Nc3ccc(C(F)(F)F)c(O[C@@H]4CCN(C)C4)c3)cc2)c1

nearest known ligand 0.62

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.62
FFAR4 Q5NUL3 1/20 0.42
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6820300 1.00 UTS2R (0.62) UTS2RFFAR4LMNA
SCHEMBL6824007 0.90 UTS2R (0.60) UTS2RFFAR4
SCHEMBL6824000 0.90 UTS2R (0.60) UTS2RFFAR4
SCHEMBL6823786 0.90 UTS2R (0.70) UTS2RLMNA
SCHEMBL6823780 0.90 UTS2R (0.70) UTS2RLMNA
SCHEMBL6824468 0.89 UTS2R (0.64) UTS2R
SCHEMBL6824460 0.89 UTS2R (0.64) UTS2R
SCHEMBL6821311 0.89 UTS2R (0.54) UTS2R
SCHEMBL6824508 0.88 UTS2R (0.64) UTS2RFFAR4
SCHEMBL6821079 0.88 UTS2R (0.64) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed