Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PPIB | P23284 | 1/20 | 0.55 |
| ▸ | PPIA | P62937 | 1/20 | 0.55 |
| ▸ | PPIG | Q13427 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA7 | P43166 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23310021 | 0.83 | POLB (0.66) | PPIDPOLBPPIBPPIAPPIG | |
| SCHEMBL9742443 | 0.83 | POLB (0.61) | PPIDPOLBPPIBPPIAPPIG | |
| SCHEMBL7345267 | 0.81 | MAPT (0.65) | PPIDPOLBPPIBPPIAPPIG | |
| SCHEMBL10499213 | 0.81 | PPID (0.63) | PPIDPOLBMAPTCA12CA1 | |
| SCHEMBL28088277 | 0.80 | POLB (0.58) | PPIDPOLBPPIBPPIAPPIG | |
| SCHEMBL6821737 | 0.80 | KMT2A (0.59) | PPIDPOLBMAPTCA12CA1 | |
| SCHEMBL5664478 | 0.79 | KMT2A (0.58) | PPIDPOLBMAPTCA12CA1 | |
| SCHEMBL4035087 | 0.79 | POLB (0.65) | PPIDPOLBMAPTCA12CA1 | |
| SCHEMBL7103590 | 0.79 | CYP4F2 (0.64) | PPIDPOLBPPIBPPIAPPIG | |
| SCHEMBL1372423 | 0.78 | POLB (0.63) | PPIDPOLBMAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004050646-A1 | 1, 2, 5-THIADIAZOLIDIN-3-ONE 1, 1 DIOXIDE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE PTP1B | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | WO | disclosed |