Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA7 | P43166 | 4/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PPID | Q08752 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664478 | 0.82 | KMT2A (0.58) | KMT2AHDAC1HDAC6PTPN1MAPT | |
| SCHEMBL12133623 | 0.81 | KMT2A (0.76) | KMT2AHDAC1HDAC6PTPN1MAPT | |
| SCHEMBL4629205 | 0.80 | CA1 (0.46) | CA12CA1CA2CA7FFAR1 | |
| SCHEMBL6821734 | 0.80 | PPID (0.65) | KMT2AHDAC1HDAC6MAPTALDH1A1 | |
| SCHEMBL5692310 | 0.79 | ALDH1A1 (0.44) | KMT2AMAPTALDH1A1POLBRAB9A | |
| Hydrochloric Acid SCHEMBL10743264 | 0.79 | KMT2A (0.58) | KMT2AHDAC1HDAC6PTPN1MAPT | |
| SCHEMBL9516674 | 0.79 | POLB (0.47) | KMT2AMAPTALDH1A1POLBRAB9A | |
| SCHEMBL11090977 | 0.79 | NAMPT (0.53) | KMT2AHDAC1HDAC6MAPTCA12 | |
| SCHEMBL5210398 | 0.78 | KMT2A (0.67) | KMT2AHDAC1HDAC6PTPN1MAPT | |
| SCHEMBL11760216 | 0.78 | SMN1; SMN2 (0.57) | KMT2AMAPTALDH1A1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004050646-A1 | 1, 2, 5-THIADIAZOLIDIN-3-ONE 1, 1 DIOXIDE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE PTP1B | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | WO | disclosed |