Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821787 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MAPTGAACA2KMT2A | |
| SCHEMBL6821024 | 0.72 | PPID (0.44) | ALDH1A1GAACA2KMT2ATSHR | |
| SCHEMBL6822123 | 0.72 | TSHR (0.52) | ALDH1A1MAPTGAAKMT2AADAMTS4 | |
| SCHEMBL6822122 | 0.72 | TSHR (0.52) | ALDH1A1MAPTGAAKMT2AADAMTS4 | |
| SCHEMBL9242992 | 0.71 | ALDH1A1 (0.61) | ALDH1A1MAPTGAACA2KMT2A | |
| SCHEMBL12133623 | 0.69 | KMT2A (0.76) | ALDH1A1MAPTGAAKMT2AHDAC1 | |
| SCHEMBL635110 | 0.69 | CA1 (0.69) | ALDH1A1MAPTCA2TSHR | |
| SCHEMBL22253301 | 0.66 | KMT2A (0.53) | ALDH1A1MAPTGAACA2KMT2A | |
| SCHEMBL2278952 | 0.66 | MAPK1 (0.54) | ALDH1A1MAPTGAAKMT2ATSHR | |
| SCHEMBL27417780 | 0.65 | KMT2A (0.43) | KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004050646-A1 | 1, 2, 5-THIADIAZOLIDIN-3-ONE 1, 1 DIOXIDE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE PTP1B | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | WO | disclosed |