Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 17/20 | 0.91 |
| ▸ | SLC6A3 | Q01959 | 17/20 | 0.91 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379467 | 1.00 | CYP3A4 (0.97) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| SCHEMBL2378403 | 1.00 | CYP3A4 (0.97) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| Hydrochloric Acid SCHEMBL2105 | 0.98 | CYP3A4 (1.00) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| Water SCHEMBL10423764 | 0.98 | CYP3A4 (0.94) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| Hydrochloric Acid SCHEMBL10336934 | 0.97 | CYP3A4 (0.97) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| SCHEMBL3517972 | 0.95 | SLC6A4 (1.00) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| SCHEMBL15065547 | 0.93 | SLC6A3 (0.85) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| SCHEMBL4606333 | 0.88 | CYP3A4 (0.76) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| Hydrochloric Acid SCHEMBL6419503 | 0.86 | CYP3A4 (0.78) | CYP3A4ALOX15TSHRTP53SLC6A4 | |
| SCHEMBL12235320 | 0.85 | CYP3A4 (0.72) | CYP3A4ALOX15TSHRTP53SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 351 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636438-A | Pharmaceutical composition comprising an AMPK activator and a serotonin active agent and uses thereof | CHEN JIANHONG | 2016-06-01 | — | — | CN | claimed |
| EP-2261203-B1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARING PROCESSES AND THE USES THEREOF | BEIJING YINGU CENTURY PHARMACY CO LTD (CN) | 2016-05-25 | — | — | EP | claimed |
| EP-2983473-A2 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS Mountain Llc (US) | 2016-02-17 | — | — | EP | claimed |
| US-20140350064-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC | 2014-11-27 | — | — | US | claimed |
| WO-2014144130-A2 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC (US) | 2014-09-18 | — | — | WO | claimed |
| US-8497305-B2 | Phenylcyclobutylamide derivatives and their stereoisomers, the preparation processes and uses thereof | YinGu Pharmaceutical Co., Ltd (CN) | 2013-07-30 | — | — | US | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| US-20110224305-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | BEIJING YINGU CENTURY PHARMACY CO. LTD (CN) | 2011-09-15 | — | — | US | claimed |
| EP-2261203-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARING PROCESSES AND THE USES THEREOF | Beijing Cachet Biomedical Co., Ltd (CN) | 2010-12-15 | — | — | EP | claimed |
| CN-101468956-A | Schiff base compound and synthesizing method thereof | BYD CO LTD (CN) | 2009-07-01 | — | — | CN | claimed |
| WO-2000056318-A1 | TREATMENT OF NEUROPATHIC PAIN OR FIBROMYALGIA | KNOLL PHARMACEUTICAL COMPANY (US) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056321-A1 | TREATMENT OF HYPERACTIVITY DISORDERS | KNOLL PHARMACEUTICAL COMPANY (US) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056307-A1 | TREATMENT OF HIATIAL HERNIA | KNOLL GMBH (DE) | 2000-09-28 | — | — | WO | claimed |
| WO-2000056306-A1 | TREATMENT OF OSTEOARTHRITIS | KNOLL GMBH (DE) | 2000-09-28 | — | — | WO | claimed |
| WO-2000054765-A1 | METHOD OF TREATING EATING DISORDERS | KNOLL GMBH (DE) | 2000-09-21 | — | — | WO | claimed |
| US-6046242-A | ADMINISTERING TO A PATIENT AN EFFECTIVE AMOUNT OF CHLOROBENZENE SUBSTITUTED CYCLOBUTYLALKYLAMINE COMPOUND TO TREAT URINARY INCONTINENCE | BASF AKTIENGESELLSCHAFT (DE) | 2000-04-04 | — | — | US | claimed |
| EP-0828484-A1 | USE OF ARYL SUBSTITUTED CYCLOBUTYL ALKYL AMINES FOR THE TREATMENT OF OBESITY | Knoll AG (DE) | 1998-03-18 | — | — | EP | claimed |
| WO-1996038134-A1 | USE OF ARYL SUBSTITUTED CYCLOBUTYL ALKYL AMINES FOR THE TREATMENT OF OBESITY | KNOLL AG (DE) | 1996-12-05 | — | — | WO | claimed |
| WO-1995021615-A1 | USE OF ARYLCYCLOBUTYLALKYLAMINES FOR THE TREATMENT OF SEIZURES AND NEUROLOGICAL DISORDERS | KNOLL AG (DE) | 1995-08-17 | — | — | WO | claimed |
| EP-0230742-B1 | N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate and pharmaceutical compositions containing it | The Boots Company PLC (GB) | 1990-09-26 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224305-A1 | PHENYLCYCLOBUTYLAMIDE DERIVATIVES AND THEIR STEREOISOMERS, THE PREPARATION PROCESSES AND USES THEREOF | AADAC, WIZ, CEBPZ | CYP3A4 628/4885ALOX15 1125/4885TSHR 2293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.