Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.51 |
| ▸ | TPMT | P51580 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828028 | 0.93 | MEN1 (0.62) | MAPK1POLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6628602 | 0.90 | POLB (0.61) | MAPK1POLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9829605 | 0.85 | ALDH1A1 (0.51) | MAPK1POLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10790468 | 0.84 | KMT2A (0.54) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL7837299 | 0.84 | ALDH1A1 (0.61) | MAPK1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9861846 | 0.84 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2ACYP1A2HPGD | |
| SCHEMBL10789209 | 0.84 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2127920 | 0.84 | KMT2A (0.66) | MAPK1POLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10516595 | 0.83 | ALDH1A1 (0.53) | MAPK1POLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9284598 | 0.82 | ALDH1A1 (0.55) | MAPK1POLBSMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912467-B1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE SA (FR) | 2002-04-24 | — | — | EP | claimed |
| EP-0812825-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-02-11 | — | — | EP | disclosed |
| US-20030225297-A1 | Process for preparing chiral diphosphines | RHODIA CHIMIE | 2003-12-04 | — | — | US | disclosed |
| US-6646106-B1 | Polymerizing chiral diphosphine having a C2 axis of symmetry, with one or several polymerizable monomers, said chiral diphosphine consisting of a chiral body bearing two identical functional groups | RHODIA CHIMIE (FR) | 2003-11-11 | — | — | US | disclosed |
| US-6610875-B1 | Forming bidentate ligands ofr assymetric catalysts; bromina-ting diaryldiol; esterifying with sulfonic acid; substituting cyano for bromine groups; coupling with a dicyclophosphine | RHODIA CHIMIE (FR) | 2003-08-26 | — | — | US | disclosed |
| US-6166257-A | METAL COMPLEX OF AN OPTICALLY ACTIVE BIS(1-PHOSPHA-2,3-DIPHENYL-4,5-DIMETHYLNORBORNADIENE) | RHODIA CHIMIE (FR) | 2000-12-26 | — | — | US | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0812825-A1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-17 | — | — | EP | disclosed |
| EP-0478147-B1 | Process for producing optically active gamma-butyrolactone derivatives | TAKASAGO PERFUMERY CO LTD (JP) | 1996-11-06 | — | — | EP | disclosed |
| US-5420306-A | Process for producing optically active γ-butyrolactone derivatives | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0478147-A1 | Process for producing optically active gamma-butyrolactone derivatives | Takasago International Corporation (JP) | 1992-04-01 | — | — | EP | disclosed |
| US-4435329-A | ANTIHYPERTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-06 | — | — | US | disclosed |
| EP-0010347-B1 | NOVEL SUBSTITUTED OMEGA-AROYL(PROPIONYL OR BUTYRYL)-L-PROLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | AMERICAN CYANAMID COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |
| US-4374249-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1983-02-15 | — | — | US | disclosed |
| US-4226775-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| EP-0010347-A1 | Novel substituted omega-aroyl(propionyl or butyryl)-L-prolines, pharmaceutical compositions containing them and processes for their preparation | AMERICAN CYANAMID COMPANY (US) | 1980-04-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225297-A1 | Process for preparing chiral diphosphines | CYP1A1, NR5A1, AR | MAPK1 367/4885POLB 737/4885SMN1; SMN2 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.