Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 3/20 | 0.69 |
| ▸ | ACHE | P22303 | 4/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.65 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.47 |
| ▸ | TUBB | P07437 | 5/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24850471 | 0.87 | PTAFR (0.54) | PTAFRACHEPTPN1MAPK3MAPK1 | |
| SCHEMBL7060832 | 0.82 | PTAFR (0.62) | PTAFRACHEPTPN1MAPK3MAPK1 | |
| SCHEMBL6159652 | 0.82 | PTAFR (0.62) | PTAFRACHEPTPN1MAPK3MAPK1 | |
| SCHEMBL6159671 | 0.82 | PTAFR (0.62) | PTAFRACHEPTPN1MAPK3MAPK1 | |
| SCHEMBL7060824 | 0.82 | PTAFR (0.62) | PTAFRACHEPTPN1MAPK3MAPK1 | |
| SCHEMBL7817198 | 0.82 | PTAFR (0.49) | PTAFRACHEPTPN1MAPK3MAPK1 | |
| SCHEMBL6159663 | 0.82 | PTAFR (0.62) | PTAFRACHEPTPN1MAPK3MAPK1 | |
| SCHEMBL7018004 | 0.82 | PTAFR (1.00) | PTAFRACHEPTPN1MEN1KMT2A | |
| SCHEMBL10456245 | 0.82 | PTAFR (1.00) | PTAFRACHEPTPN1MEN1KMT2A | |
| SCHEMBL7018006 | 0.82 | PTAFR (1.00) | PTAFRACHEPTPN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812825-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-02-11 | — | — | EP | disclosed |
| US-20020091120-A1 | 2-substituted heterocyclic compounds for treating multidrug resistance | PROCTER & GAMBLE COMPANY, THE | 2002-07-11 | — | — | US | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| CN-1172476-A | Propenone derivatives | KYOWA HAKKO KOGYO KK (JP) | 1998-02-04 | — | — | CN | disclosed |
| EP-0812825-A1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091120-A1 | 2-substituted heterocyclic compounds for treating multidrug resistance | ABCC1, ABCB1, ABCB11 | PTAFR 1270/4885ACHE 3787/4885PTPN1 3326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.