Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | MGLL | Q99685 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658016 | 0.89 | CNR1 (0.44) | GPR119MGLL | |
| SCHEMBL6778252 | 0.84 | GPR119 (0.46) | GPR119MGLLOPRD1OPRK1STS | |
| SCHEMBL31585625 | 0.83 | KDM4E (0.47) | GPR119MGLLKDM4EPKMALOX15 | |
| SCHEMBL16466248 | 0.82 | FFAR4 (0.50) | GPR119MGLLKDM4EPKMSMN1; SMN2 | |
| SCHEMBL20396156 | 0.82 | NR1H2 (0.48) | GPR119MGLLSMN1; SMN2NAMPT | |
| SCHEMBL18418311 | 0.82 | MGLL (0.52) | GPR119MGLLOPRD1OPRK1TACR1 | |
| SCHEMBL22880757 | 0.82 | MGLL (0.52) | GPR119MGLLOPRD1OPRK1TACR1 | |
| SCHEMBL24753001 | 0.81 | USP2 (0.42) | GPR119MGLLSMN1; SMN2NAMPT | |
| SCHEMBL22880963 | 0.81 | USP2 (0.42) | GPR119MGLLSMN1; SMN2NAMPT | |
| SCHEMBL29319166 | 0.81 | CYP2D6 (0.46) | GPR119MGLLOPRD1OPRK1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058763-A1 | 4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |