Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 7/20 | 0.56 |
| ▸ | RARG | P13631 | 6/20 | 0.56 |
| ▸ | RARA | P10276 | 5/20 | 0.56 |
| ▸ | RXRA | P19793 | 17/20 | 0.51 |
| ▸ | RXRB | P28702 | 9/20 | 0.51 |
| ▸ | RXRG | P48443 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318880 | 0.74 | RXRA (0.57) | RARBRARGRARARXRARXRB | |
| SCHEMBL156460 | 0.72 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL10841477 | 0.72 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL8200200 | 0.72 | RARG (0.52) | RARBRARGRARARXRARXRB | |
| SCHEMBL8200207 | 0.72 | RARG (0.52) | RARBRARGRARARXRARXRB | |
| Hydrochloric Acid SCHEMBL4432609 | 0.71 | RARB (0.97) | RARBRARGRARARXRARXRB | |
| SCHEMBL7879841 | 0.70 | RARG (0.62) | RARBRARGRARARXRARXRB | |
| SCHEMBL7879838 | 0.70 | RARG (0.62) | RARBRARGRARARXRARXRB | |
| SCHEMBL14782243 | 0.70 | RARB (0.65) | RARBRARGRARARXRARXRB | |
| SCHEMBL9117389 | 0.69 | RARG (0.49) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004072042-A2 | QUINOLINE DERIVATIVE AND THEIR USE FOR MODULATION OF LXR ACTIVITY | CAREX S.A. (FR) | 2004-08-26 | — | — | WO | disclosed |
| WO-2004072046-A2 | QUINOLINE DERIVATIVES AND THEIR USE FOR MODULATION OF LXR ACTIVITY | CAREX S.A. (FR) | 2004-08-26 | — | — | WO | disclosed |
| US-20030104975-A1 | Cofactor-based screening method for nuclear receptor modulators and related modulators | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM) (FR) | 2003-06-05 | — | — | US | disclosed |
| EP-1267171-A1 | Cofactor-based screening method for nuclear receptor modulators | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-12-18 | — | — | EP | disclosed |
| WO-2002094877-A2 | NEW NUCLEAR RECEPTOR COFACTORS AND RELATED MODULATORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-11-28 | — | — | WO | disclosed |
| US-6333318-B1 | USED IN THERAPY; FOR DELIVERING RECOMBINANT PROTEINS INTO A VARIETY OF CELLS WITHIN A PATIENT | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2001-12-25 | — | — | US | disclosed |