Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823620 | 1.00 | ACHE (0.51) | ACHELMNACYP3A4KDM4EGAA | |
| SCHEMBL418274 | 0.94 | ACHE (0.56) | ACHELMNACYP3A4KDM4EGAA | |
| SCHEMBL1490220 | 0.83 | ACHE (0.46) | ACHELMNACYP3A4KDM4EGAA | |
| SCHEMBL12332900 | 0.81 | HSD17B10 (0.54) | ACHELMNACYP3A4KDM4EGAA | |
| SCHEMBL5682633 | 0.79 | ACHE (0.61) | ACHELMNACYP3A4KDM4EGAA | |
| SCHEMBL50809 | 0.79 | CYP3A4 (0.62) | ACHELMNACYP3A4KDM4EGAA | |
| SCHEMBL862851 | 0.79 | ACHE (0.65) | ACHELMNACYP3A4KDM4EGAA | |
| SCHEMBL28670923 | 0.79 | ELANE (0.53) | ACHEKDM4EGAAALDH1A1MAPT | |
| SCHEMBL2813313 | 0.79 | ACHE (0.59) | ACHEKDM4EGAAGLAALDH1A1 | |
| SCHEMBL17242112 | 0.78 | MEN1 (0.53) | ACHEMAPTTP53POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379492-A1 | INHIBITOR OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002070457-A1 | INHIBITOR OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2002-09-12 | — | — | WO | disclosed |