Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594899 | 0.87 | KMT2A (0.63) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL6823411 | 0.79 | KMT2A (0.53) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL27587733 | 0.78 | MAPT (0.48) | KMT2AMEN1TDP1MAPTALDH1A1 | |
| SCHEMBL27587741 | 0.77 | CYP19A1 (0.51) | KMT2AMEN1MAPTALDH1A1PPIA | |
| SCHEMBL27587708 | 0.77 | PKM (0.50) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL7489708 | 0.76 | ALDH1A1 (0.41) | KMT2AMEN1TDP1MAPTALDH1A1 | |
| SCHEMBL7549869 | 0.76 | MEN1 (0.62) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL3710415 | 0.75 | KMT2A (0.68) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL6820169 | 0.75 | KMT2A (0.68) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL28752712 | 0.75 | KMT2A (0.43) | KMT2AMEN1TDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |