Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.87 |
| ▸ | NPC1 | O15118 | 1/20 | 0.87 |
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | XPO1 | O14980 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669614 | 0.92 | MAPT (0.82) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL7668189 | 0.87 | MEN1 (0.88) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL7669067 | 0.86 | MAPT (0.67) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25011042 | 0.82 | ALDH1A1 (0.70) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL7698773 | 0.81 | MEN1 (0.58) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL7544665 | 0.80 | KMT2A (0.57) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25011068 | 0.80 | ALDH1A1 (0.67) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25011044 | 0.79 | ALDH1A1 (0.65) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL7694832 | 0.79 | MEN1 (0.71) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25011092 | 0.77 | TP53 (0.72) | MEN1KMT2ANPC1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002100842-A1 | SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS | MERCK PATENT GMBH (DE) | 2002-12-19 | — | — | WO | claimed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | claimed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | claimed |
| US-6737426-B1 | SUCH AS (4-PHENYLSULFONYL-2-PYRIDIN-3-YL-OXAZOL-5-YL)-METHYLAMINE; ANTICONVULSANTS, ANTIINFLAMMATORIES, NEURO-PROTECTANTS, CEREBROPROTECTANTS, NOOTROPICS | MERCK PATENT GMBH (DE) | 2004-05-18 | — | — | US | disclosed |
| WO-2002100842-A1 | SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS | MERCK PATENT GMBH (DE) | 2002-12-19 | — | — | WO | disclosed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |