Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.88 |
| ▸ | NPC1 | O15118 | 1/20 | 0.88 |
| ▸ | MAPT | P10636 | 7/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | XPO1 | O14980 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823671 | 0.87 | MEN1 (0.87) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL7670728 | 0.83 | MEN1 (0.65) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25009628 | 0.81 | MAPT (0.80) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25010448 | 0.80 | ALDH1A1 (0.77) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25009644 | 0.79 | TP53 (0.64) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL7669614 | 0.79 | MAPT (0.82) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25009171 | 0.77 | MAPT (0.65) | MEN1KMT2ANPC1MAPTTDP1 | |
| SCHEMBL25009351 | 0.77 | ALDH1A1 (0.67) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL25009348 | 0.75 | MAPT (0.67) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL25009353 | 0.75 | MAPT (0.66) | MEN1KMT2ANPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002100842-A1 | SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS | MERCK PATENT GMBH (DE) | 2002-12-19 | — | — | WO | disclosed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |