Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 4/20 | 0.30 |
| ▸ | ACE | P12821 | 4/20 | 0.30 |
| ▸ | ECE1 | P42892 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14811593 | 0.97 | — | — | |
| SCHEMBL31557611 | 0.94 | TSHR (0.38) | TSHRMMEACEECE1 | |
| SCHEMBL31557612 | 0.88 | TSHR (0.38) | TSHRMMEACEECE1 | |
| Ammonia Solution, Strong SCHEMBL2457320 | 0.87 | — | — | |
| SCHEMBL25365911 | 0.83 | NR1H2 (0.34) | TSHR | |
| SCHEMBL1760719 | 0.83 | NR1H2 (0.34) | TSHR | |
| Dimethylamine SCHEMBL29203962 | 0.73 | ACHE (0.32) | — | |
| SCHEMBL27603876 | 0.71 | CCNB2 (0.31) | — | |
| SCHEMBL9566479 | 0.70 | ACHE (0.43) | MMEACEECE1 | |
| Ammonia Solution, Strong SCHEMBL3063865 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119543-B1 | N-ARALKYLAMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR | ORTHO MCNEIL PHARM INC (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1119543-A1 | N-ARALKYLAMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-08-01 | — | — | EP | disclosed |
| US-6201025-B1 | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-03-13 | — | — | US | disclosed |
| WO-2000020376-A1 | N-ARALKYLAMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-04-13 | — | — | WO | disclosed |