Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.80 |
| ▸ | MAPT | P10636 | 4/20 | 0.80 |
| ▸ | GAA | P10253 | 2/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.73 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594883 | 1.00 | ALDH1A1 (0.80) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL7485596 | 0.95 | CXCR2 (0.83) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL11674249 | 0.89 | MAPT (1.00) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL28432107 | 0.86 | ALDH1A1 (0.60) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL31222305 | 0.84 | CXCR2 (1.00) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL5595180 | 0.84 | CXCR2 (1.00) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL3708178 | 0.84 | CXCR2 (0.79) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL5078630 | 0.82 | ALDH1A1 (0.79) | ALDH1A1MAPTGAAHPGDSMN1; SMN2 | |
| SCHEMBL28433444 | 0.82 | RAB9A (0.72) | ALDH1A1MAPTGAAHPGDCXCR1 | |
| SCHEMBL25250303 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MAPTGAAHPGDCXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |