SCHEMBL6823769

SCHEMBL6823769

COc1ccc2c(-c3ccc(O)cc3)c(Oc3ccc(OCc4ccccc4)cc3)c(=O)oc2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.53
ACHE P22303 2/20 0.53
ESR1 P03372 6/20 0.52
MGAM O43451 3/20 0.52
GAA P10253 3/20 0.52
SI P14410 3/20 0.52
MGAM2 Q2M2H8 3/20 0.52
CYP19A1 P11511 3/20 0.52
MAOA P21397 1/20 0.49
NPC1 O15118 1/20 0.48
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 1/20 0.48
TP53 P04637 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
MAPT P10636 1/20 0.48
CYP2C9 P11712 1/20 0.48
HPGD P15428 1/20 0.48
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6823816 0.91 ALDH1A1 (0.55) MAOBESR1GAACYP19A1NPC1
SCHEMBL6823709 0.90 ALDH1A1 (0.54) MAOBESR1GAACYP19A1NPC1
SCHEMBL6823739 0.88 ESR1 (0.67) MAOBACHEESR1CYP19A1MAOA
SCHEMBL6825824 0.88 NPC1 (0.61) MAOBESR1NPC1KDM4EMEN1
SCHEMBL6823032 0.83 CA1 (0.56) ESR1GAACYP19A1NPC1KDM4E
SCHEMBL28085675 0.81 MAOB (0.65) MAOBACHECYP19A1MAOANPC1
SCHEMBL6922082 0.80 ESR1 (0.73) ACHEESR1
SCHEMBL6922106 0.80 ESR1 (0.72) ACHEESR1
SCHEMBL8958533 0.78 MAOB (0.59) MAOBACHEMAOANPC1KDM4E
SCHEMBL6823324 0.77 ESR1 (0.77) ACHEESR1NPC1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004069820-A1 COUMARIN DERIVATIVES HAVING AN AFFINITY FOR OESTROGEN RECEPTORS, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME B.F.B. ETUDES ET RECHERCHES EXPERIMENTALES (FR) 2004-08-19 WO disclosed