Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6724579 | 1.00 | REN (0.54) | RENSLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL6724774 | 0.89 | REN (0.56) | REN | |
| SCHEMBL6825432 | 0.88 | REN (0.71) | REN | |
| SCHEMBL6724548 | 0.88 | REN (0.71) | REN | |
| SCHEMBL6721665 | 0.86 | REN (0.54) | REN | |
| SCHEMBL7065291 | 0.86 | REN (0.54) | REN | |
| SCHEMBL8303226 | 0.86 | REN (0.56) | REN | |
| SCHEMBL6825128 | 0.82 | REN (0.60) | REN | |
| SCHEMBL6727994 | 0.82 | REN (0.60) | REN | |
| SCHEMBL6721597 | 0.82 | REN (0.56) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |