SCHEMBL6825511

SCHEMBL6825511

CC(=O)Nc1ccc2c(C=O)c[nH]c2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.53
KDM4E B2RXH2 4/20 0.52
ALDH1A1 P00352 4/20 0.52
MAPT P10636 1/20 0.52
PLG P00747 1/20 0.50
PLAU P00749 1/20 0.50
MAOA P21397 1/20 0.48
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
POLB P06746 2/20 0.47
ERCC1 P07992 1/20 0.47
FEN1 P39748 1/20 0.47
ERCC4 Q92889 1/20 0.47
KIF11 P52732 1/20 0.47
IMPDH2 P12268 1/20 0.46
MTNR1A P48039 2/20 0.44
MTNR1B P49286 2/20 0.44
HPGD P15428 2/20 0.44
TP53 P04637 1/20 0.44
HSD17B10 Q99714 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18311437 0.88 ALDH1A1 (0.52) CYP2A6KDM4EALDH1A1MAOAKMT2A
SCHEMBL9478253 0.76 LMNA (0.54) CYP2A6KDM4EALDH1A1MAPTPLG
SCHEMBL16112737 0.74 ALDH1A1 (0.56) KDM4EALDH1A1MAOAKMT2AMEN1
SCHEMBL212820 0.73 PLG (0.61) CYP2A6KDM4EALDH1A1MAPTPLG
SCHEMBL2539100 0.73 ALDH1A1 (0.49) CYP2A6KDM4EALDH1A1POLBIMPDH2
SCHEMBL16111463 0.73 ERCC1 (0.56) KDM4EALDH1A1MAOAKMT2AERCC1
SCHEMBL1049957 0.73 PIM3 (0.65) CYP2A6KDM4EALDH1A1MAPTPLG
SCHEMBL29935657 0.73 PIM3 (0.65) CYP2A6KDM4EALDH1A1MAPTPLG
SCHEMBL29958258 0.73 CYP2A6 (0.64) CYP2A6KDM4EALDH1A1MAPTPLG
SCHEMBL15324073 0.73 CYP2A6 (0.64) CYP2A6KDM4EALDH1A1MAPTPLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0812825-B1 PROPENONE DERIVATIVES KYOWA HAKKO KOGYO KK (JP) 2004-02-11 EP disclosed
EP-0680950-B1 PROPENONE DERIVATIVES KYOWA HAKKO KOGYO KK (JP) 2001-05-23 EP disclosed
US-5952355-A 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION KYOWA HAKKO KOGYO CO., LTD. (JP) 1999-09-14 US disclosed
CN-1172476-A Propenone derivatives KYOWA HAKKO KOGYO KK (JP) 1998-02-04 CN disclosed
EP-0812825-A1 PROPENONE DERIVATIVES KYOWA HAKKO KOGYO CO., LTD. (JP) 1997-12-17 EP disclosed
EP-0680950-A1 PROPENONE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD. (JP) 1995-11-08 EP disclosed