Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 3/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825653 | 0.86 | CYP2A6 (0.45) | CYP2A6CYP2C9CYP2E1CYP2B6CYP2C19 | |
| SCHEMBL6827688 | 0.83 | CYP2A6 (0.42) | CYP2A6CYP2C9CYP2E1CYP2B6CYP2C19 | |
| SCHEMBL6825776 | 0.82 | MAP4K4 (0.39) | — | |
| SCHEMBL6825816 | 0.74 | GRM1 (0.39) | CYP2A6CYP2C9CYP3A4MAPK1LMNA | |
| SCHEMBL6822491 | 0.74 | MAPK1 (0.41) | CYP2C9CYP2C19CYP3A4LATS1LATS2 | |
| SCHEMBL8305400 | 0.72 | KDM4E (0.39) | LATS1LATS2PDE10AMAPK1CYP11B1 | |
| SCHEMBL6825743 | 0.72 | LATS1 (0.37) | LATS1LATS2MAPK1CYP11B1LMNA | |
| SCHEMBL6825731 | 0.70 | LATS1 (0.38) | LATS1LATS2LMNANPSR1KMT2A | |
| SCHEMBL6825775 | 0.68 | MAP4K4 (0.40) | — | |
| SCHEMBL27249454 | 0.68 | CYP17A1 (0.47) | CYP2A6CYP2C9CYP2E1CYP2B6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214833-A1 | Tricyclic heteroaromatic compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-10-28 | — | — | US | claimed |
| WO-2004089950-A1 | TRICYCLIC HETEROAROMATIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-10-21 | — | — | WO | claimed |
| US-20040214833-A1 | Tricyclic heteroaromatic compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-10-28 | — | — | US | disclosed |
| WO-2004089950-A1 | TRICYCLIC HETEROAROMATIC COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214833-A1 | Tricyclic heteroaromatic compounds | CYP1A1, SULT2A1, CYP1B1 | CYP2A6 18/4885CYP2C9 16/4885CYP2E1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.