Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 12/20 | 0.57 |
| ▸ | TUBB | P07437 | 12/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 12/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 12/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 12/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 12/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 12/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 12/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 12/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 12/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 12/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 12/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 12/20 | 0.57 |
| ▸ | TUBB2B | Q9BVA1 | 12/20 | 0.57 |
| ▸ | TUBB1 | Q9H4B7 | 12/20 | 0.57 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466150 | 0.80 | ESR1 (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL31744823 | 0.80 | TUBB4A (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28461532 | 0.79 | ESR1 (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL12778109 | 0.78 | ALDH1A1 (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6995871 | 0.78 | TUBB4A (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL11790792 | 0.78 | ESR1 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10648743 | 0.78 | MAPT (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10647311 | 0.78 | KMT2A (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL670200 | 0.76 | AHR (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4208427 | 0.76 | KDM4E (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106957254-B | A kind of 3- alkoxyalkyl indole derivatives and its preparation method and application | 郑州大学 | 2019-11-15 | — | — | CN | disclosed |
| CN-106957254-A | A kind of 3 alkoxyalkyl indole derivativeses and its preparation method and application | 郑州大学 | 2017-07-18 | — | — | CN | disclosed |
| US-9604974-B2 | Compounds as modulator of JAK-STAT pathway, methods and applications thereof | UNIVERSITY OF MYSORE (IN) | 2017-03-28 | — | — | US | disclosed |
| US-20160214968-A1 | COMPOUNDS AS MODULATOR OF JAK-STAT PATHWAY, METHODS AND APPLICATIONS THEREOF | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2016-07-28 | — | — | US | disclosed |
| CN-102036972-A | Treatment of duchenne muscular dystrophy | SUMMIT CORP PLC | 2011-04-27 | — | — | CN | disclosed |
| WO-2004099139-A1 | INDOLE-CONTAINING COMPOUNDS WITH ANTI-TUBULIN AND VASCULAR TARGETING ACTIVITY | BAYLOR UNIVERSITY (US) | 2004-11-18 | — | — | WO | disclosed |
| WO-2002081444-A1 | 1-INDOLYL DERIVATIVES, USE THEREOF FOR PRODUCTION OF MEDICAMENTS, A METHOD FOR PRODUCTION OF SAID 1-INDOLYL DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING 1-INDOLYL DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214968-A1 | COMPOUNDS AS MODULATOR OF JAK-STAT PATHWAY, METHODS AND APPLICATIONS THEREOF | STAT3, STAT1, JAK2 | TUBB4A 1979/4885TUBB 1673/4885TUBA3C 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.