Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 12/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823918 | 0.90 | PTK2 (0.47) | PTK2ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6823920 | 0.89 | PTK2 (0.45) | PTK2MEN1KMT2AHTR7UTS2R | |
| SCHEMBL6824418 | 0.84 | HTR7 (0.40) | PTK2MEN1KMT2AHTR7UTS2R | |
| SCHEMBL6824544 | 0.83 | HTR7 (0.40) | PTK2MEN1KMT2AHTR7UTS2R | |
| SCHEMBL6826210 | 0.82 | PTK2 (0.44) | PTK2HTR7UTS2RHTR1ACYP2D6 | |
| SCHEMBL6820544 | 0.81 | UTS2R (0.38) | PTK2MEN1KMT2AHTR7UTS2R | |
| SCHEMBL6820571 | 0.80 | PTK2 (0.49) | PTK2HTR7UTS2RHTR1ADRD2 | |
| SCHEMBL6824127 | 0.74 | HTR7 (0.45) | PTK2HTR7UTS2RACHEHTR1A | |
| SCHEMBL6824129 | 0.73 | HTR7 (0.43) | MEN1KMT2AHTR7UTS2RHTR1A | |
| SCHEMBL6824422 | 0.67 | HTR7 (0.42) | HTR7UTS2RHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | claimed |
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | disclosed |