Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.60 |
| ▸ | KDR | P35968 | 12/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6831400 | 0.86 | SRC (0.64) | SRCKDREGFR | |
| SCHEMBL7128594 | 0.84 | SRC (0.69) | SRCKDREGFR | |
| SCHEMBL6829226 | 0.84 | SRC (0.69) | SRCKDREGFR | |
| SCHEMBL6819634 | 0.82 | SRC (0.61) | SRCKDREGFRMKNK1MKNK2 | |
| SCHEMBL6823586 | 0.82 | SRC (0.61) | SRCKDREGFRMKNK1MKNK2 | |
| SCHEMBL6829839 | 0.82 | SRC (0.60) | SRCKDREGFRMKNK1MKNK2 | |
| SCHEMBL6829449 | 0.81 | SRC (0.60) | SRCKDREGFR | |
| SCHEMBL6823799 | 0.77 | EGFR (0.52) | SRCKDREGFR | |
| SCHEMBL7068520 | 0.76 | SRC (0.63) | SRCKDREGFR | |
| SCHEMBL3280052 | 0.76 | SRC (0.67) | SRCKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108711-A1 | PYRAZINIL QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | WO | disclosed |