Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 11/20 | 0.42 |
| ▸ | SRC | P12931 | 9/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.41 |
| ▸ | KIF5B | P33176 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819594 | 0.82 | EGFR (0.57) | EGFRKDRSRC | |
| SCHEMBL6823640 | 0.81 | EGFR (0.54) | EGFRKDRSRCRETLCK | |
| SCHEMBL6831400 | 0.79 | SRC (0.64) | EGFRKDRSRCRETKIF5B | |
| SCHEMBL6823586 | 0.79 | SRC (0.61) | EGFRKDRSRCRETKIF5B | |
| SCHEMBL6826353 | 0.77 | SRC (0.60) | EGFRKDRSRC | |
| SCHEMBL6825683 | 0.75 | SRC (0.74) | EGFRKDRSRC | |
| SCHEMBL3280052 | 0.75 | SRC (0.67) | EGFRKDRSRCRETKIF5B | |
| SCHEMBL6829839 | 0.73 | SRC (0.60) | EGFRKDRSRCRETKIF5B | |
| SCHEMBL6819634 | 0.73 | SRC (0.61) | EGFRKDRSRC | |
| SCHEMBL27573718 | 0.69 | KDR (0.48) | EGFRKDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004056812-A1 | 4- (PYRIDIN-4-YLAMINO) -QUINAZOLINE DERIVATIVES AS ANTI-TUMOR AGENTS | ASTRAZENECA AB (SE) | 2004-07-08 | — | — | WO | disclosed |