Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 10/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826380 | 0.85 | CA12 (0.49) | MAPTLMNAMEN1NPC1ALDH1A1 | |
| SCHEMBL4205641 | 0.80 | PIM1 (0.71) | PIM1PIM2PIM3 | |
| SCHEMBL28434682 | 0.73 | KDM4E (0.69) | MAPTLMNAMEN1NPC1ALDH1A1 | |
| SCHEMBL8542497 | 0.71 | MAPT (0.53) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL23579967 | 0.69 | NQO2 (0.41) | MAPTLMNAALDH1A1L3MBTL1PIM1 | |
| SCHEMBL11419219 | 0.68 | MAPT (0.53) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL9143559 | 0.68 | CA12 (0.51) | MAPTLMNAMEN1NPC1ALDH1A1 | |
| SCHEMBL23580759 | 0.67 | RIPK1 (0.43) | MAPTLMNAMEN1NPC1ALDH1A1 | |
| SCHEMBL3121586 | 0.67 | CA12 (0.56) | MAPTLMNAMEN1NPC1ALDH1A1 | |
| SCHEMBL7486947 | 0.66 | PKN1 (0.52) | MAPTMEN1ALDH1A1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111052-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) | XENOVA LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |