Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439013 | 0.86 | KDM4E (0.70) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL28432878 | 0.85 | KDM4E (0.64) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL6753969 | 0.84 | KDM4E (0.79) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL18459774 | 0.82 | MAPT (0.76) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL8601357 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL18426060 | 0.81 | MAPT (0.74) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL9642133 | 0.81 | MAPT (1.00) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL16061454 | 0.81 | MAPT (0.74) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL1539990 | 0.81 | ALDH1A1 (0.74) | KDM4EALDH1A1MAPTKCNJ1LMNA | |
| SCHEMBL521103 | 0.81 | PKM (0.75) | KDM4EALDH1A1MAPTKCNJ1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | disclosed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | disclosed |