⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10433346 | 1.00 | — | — | |
| SCHEMBL18823383 | 0.83 | — | — | |
| SCHEMBL18712322 | 0.83 | — | — | |
| SCHEMBL18823486 | 0.83 | — | — | |
| SCHEMBL6827518 | 0.79 | ADH1B (0.39) | — | |
| SCHEMBL271892 | 0.77 | — | — | |
| SCHEMBL24138686 | 0.75 | ADH1B (0.43) | — | |
| SCHEMBL9760970 | 0.75 | AKR1B1 (0.36) | — | |
| SCHEMBL2702509 | 0.74 | — | — | |
| SCHEMBL105725 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1523493-B1 | NOVEL TUBULYSIN ANALOGUES | DOEMLING ALEXANDER (DE) | 2013-09-04 | — | — | EP | disclosed |
| US-7816377-B2 | Tubulysin analogues | R&D-BIOPHARMACEUTICALS GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-7816377-B2 | Tubulysin analogues | R&D-BIOPHARMACEUTICALS GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-20040067999-A1 | Carbazole derivatives and their use as neuropeptide y5 receptor ligands | ASTRAZENECA AB (SE) | 2004-04-08 | — | — | US | disclosed |
| EP-1358157-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002051806-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |
| EP-0353732-A2 | Fluoro-olefins, method for their preparation and their use | CIBA-GEIGY AG (CH) | 1990-02-07 | — | — | EP | disclosed |