Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 13/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 10/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 10/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | BUB1 | O43683 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518782 | 1.00 | MAPK10 (1.00) | MAPK10MAPK8MAPK14RAB9APIP5K1C | |
| SCHEMBL6037694 | 0.94 | MAPK10 (0.89) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518962 | 0.90 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518648 | 0.90 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518865 | 0.79 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518802 | 0.79 | MAPK10 (0.69) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL21068073 | 0.79 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518805 | 0.79 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL17223597 | 0.79 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL1518930 | 0.78 | MAPK10 (1.00) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | claimed |
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |