Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 13/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.69 |
| ▸ | CDK9 | P50750 | 3/20 | 0.59 |
| ▸ | BUB1 | O43683 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.51 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518733 | 0.95 | MAPK10 (0.72) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL5814782 | 0.82 | MAPK10 (0.52) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL1518865 | 0.81 | MAPK10 (1.00) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA | |
| SCHEMBL2449552 | 0.79 | ULK1 (0.56) | CDK9 | |
| SCHEMBL1518782 | 0.79 | MAPK10 (1.00) | MAPK10MAPK14MAPK8BUB1GSK3B | |
| SCHEMBL6826851 | 0.79 | MAPK10 (1.00) | MAPK10MAPK14MAPK8BUB1GSK3B | |
| SCHEMBL21068073 | 0.79 | MAPK10 (1.00) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL1518805 | 0.79 | MAPK10 (1.00) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL17223597 | 0.79 | MAPK10 (1.00) | MAPK10MAPK14MAPK8CDK9BUB1 | |
| SCHEMBL1518834 | 0.79 | MAPK10 (1.00) | MAPK10MAPK14MAPK8PIP5K1CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897572-B1 | Theraputic methods for type I diabetes | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL (US) | 2011-03-01 | — | — | US | disclosed |