SCHEMBL6827799

SCHEMBL6827799

Cc1cc(NC(CC(C)C)C(=O)O)cc(Cl)n1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.48
HTT P42858 1/20 0.48
GRN P28799 3/20 0.45
SORT1 Q99523 3/20 0.45
MAPK1 P28482 2/20 0.42
ALDH1A1 P00352 3/20 0.39
LMNA P02545 1/20 0.39
ACE2 Q9BYF1 4/20 0.38
ACE P12821 3/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPK8 P45983 1/20 0.38
CYP2C19 P33261 1/20 0.38
MEN1 O00255 1/20 0.37
CYP2C9 P11712 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6825316 0.78 MAPT (0.45) MAPTHTTGRNSORT1MAPK1
SCHEMBL5672221 0.76 MAPT (0.49) MAPTHTTGRNSORT1MAPK1
SCHEMBL11198315 0.73 ALDH1A1 (0.57) MAPTHTTGRNSORT1MAPK1
SCHEMBL11198311 0.73 ALDH1A1 (0.57) MAPTHTTGRNSORT1MAPK1
SCHEMBL6705695 0.72 GRN (0.62) MAPTHTTGRNSORT1MAPK1
SCHEMBL6705696 0.72 GRN (0.62) MAPTHTTGRNSORT1MAPK1
SCHEMBL9110379 0.72 S1PR2 (0.57) HTTSORT1MAPK1ALDH1A1LMNA
SCHEMBL30248286 0.71 MAPK1 (0.71) MAPTHTTGRNSORT1MAPK1
SCHEMBL11200746 0.71 ALDH1A1 (0.51) MAPTMAPK1ALDH1A1LMNACYP2C19
SCHEMBL11200751 0.71 ALDH1A1 (0.51) MAPTMAPK1ALDH1A1LMNACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004069829-A1 (2S)-2-((PYRIMIDIN-4-YL)AMINO)-4-METHYLPENTANOIC ACID AMINOETHYLAMID DERIVATIVES AS IL-8 RECEPTOR MODULATORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND RHEUMATOID ARTHRITIS PHARMACOPEIA DRUG DISCOVERY, INC. (US) 2004-08-19 WO disclosed