Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.59 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18776378 | 0.86 | MAPT (0.52) | ALDH1A1KDM4EPOLBMEN1MAPT | |
| SCHEMBL11519150 | 0.82 | POLB (0.59) | ALDH1A1KDM4EPOLBMEN1MAPT | |
| SCHEMBL6266901 | 0.78 | POLB (0.67) | ALDH1A1KDM4EPOLBMEN1MAPT | |
| SCHEMBL13384696 | 0.77 | ACHE (0.59) | ALDH1A1KDM4EPOLBMAPTKMT2A | |
| SCHEMBL30686944 | 0.77 | ACHE (0.59) | ALDH1A1KDM4EPOLBMAPTKMT2A | |
| SCHEMBL2378537 | 0.74 | ACHE (0.62) | ALDH1A1KDM4EPOLBMEN1MAPT | |
| SCHEMBL17734346 | 0.74 | ACHE (0.54) | ALDH1A1MAPTMAPK1HTTPRKCI | |
| SCHEMBL28891187 | 0.73 | MAPT (0.53) | ALDH1A1KDM4EPOLBMEN1MAPT | |
| SCHEMBL15383502 | 0.73 | AMY1A (0.61) | ALDH1A1KDM4EPOLBMEN1MAPT | |
| SCHEMBL27728788 | 0.73 | ACHE (0.59) | ALDH1A1KDM4EPOLBMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025114-B1 | 3'-N-MODIFIED 6-O-SUBSTITUTED ERYTHROMYCIN KETOLIDE DERIVATIVES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LAB (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1025114-A1 | 3'-N-MODIFIED 6-O-SUBSTITUTED ERYTHROMYCIN KETOLIDE DERIVATIVES HAVING ANTIBACTERIAL ACTIVITY | Abbott Laboratories (US) | 2000-08-09 | — | — | EP | disclosed |
| US-6034069-A | 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity | ABBOTT LABORATORIES (US) | 2000-03-07 | — | — | US | disclosed |
| WO-1999016779-A1 | 3'-N-MODIFIED 6-O-SUBSTITUTED ERYTHROMYCIN KETOLIDE DERIVATIVES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1999-04-08 | — | — | WO | disclosed |
| EP-0329268-A2 | Glass ionomer dental cement curable in two stages | Kerr Manufacturing Company (a Delaware corporation) (US) | 1989-08-23 | — | — | EP | disclosed |