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Sugi Predict / Compounds / SCHEMBL6828089

SCHEMBL6828089

SCHEMBL6828089

Cc1cc(C2=CCN(S(=O)(=O)C[C@@]3(C)NC(=O)NC3=O)CC2)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MMP13 P45452 13/20 0.47
▸ MMP12 P39900 5/20 0.46
▸ MMP2 P08253 6/20 0.43
▸ MMP3 P08254 5/20 0.43
▸ CCNT1 O60563 1/20 0.43
▸ CDK9 P50750 1/20 0.43
▸ MMP14 P50281 4/20 0.41
▸ ADAMTS5 Q9UNA0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL942640 0.88 MMP13 (0.58) MMP13MMP12MMP2MMP14ADAMTS5
SCHEMBL8272987 0.88 MMP13 (0.47) MMP13MMP12MMP14
SCHEMBL6920418 0.86 MMP13 (0.42) MMP13MMP12MMP2MMP3MMP14
SCHEMBL6920415 0.86 MMP13 (0.42) MMP13MMP12MMP2MMP3MMP14
SCHEMBL7158166 0.86 MMP13 (0.42) MMP13MMP12MMP2MMP3MMP14
SCHEMBL941447 0.82 MMP13 (0.55) MMP13MMP12MMP14
SCHEMBL6922996 0.80 GPR119 (0.43) MMP13MMP12MMP2MMP3MMP14
SCHEMBL6926427 0.78 MMP13 (0.44) MMP13MMP12MMP14
SCHEMBL8133854 0.78 MMP13 (0.42) MMP13MMP12MMP2MMP3MMP14
SCHEMBL8149989 0.77 MMP13 (0.40) MMP13MMP12MMP2MMP3MMP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004024718-A1 IMIDAZOLIDINEDIONE-DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITORS ASTRAZENECA AB (SE) 2004-03-25 — — WO claimed