Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250298 | 0.76 | TRPV1 (0.43) | TRPV1ROCK2 | |
| SCHEMBL13841567 | 0.71 | ROCK2 (0.73) | ROCK2CCR2ROCK1SIGMAR1 | |
| SCHEMBL1351416 | 0.71 | TRPV1 (0.69) | TRPV1 | |
| SCHEMBL1351421 | 0.71 | TRPV1 (0.69) | TRPV1 | |
| SCHEMBL6923155 | 0.70 | ROCK2 (0.42) | TRPV1ROCK2CCR2ROCK1MTNR1A | |
| SCHEMBL14860966 | 0.70 | EPHX1 (0.70) | TRPV1ROCK2ROCK1 | |
| SCHEMBL13595613 | 0.69 | EPHX1 (0.72) | TRPV1 | |
| SCHEMBL4780302 | 0.67 | TRPV1 (0.52) | TRPV1KDM4E | |
| SCHEMBL5659541 | 0.67 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL12135952 | 0.66 | TRPV1 (0.62) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024710-A1 | UREA COMPOUNDS ACTIVE AS VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |