Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250298 | 0.72 | TRPV1 (0.43) | ROCK2TRPV1 | |
| SCHEMBL6828091 | 0.70 | TRPV1 (0.43) | ROCK2ROCK1MTNR1AMTNR1BTRPV1 | |
| SCHEMBL27649150 | 0.69 | CDK8 (0.47) | — | |
| SCHEMBL5802241 | 0.67 | KDM4E (0.48) | P2RX7TRPV1 | |
| SCHEMBL14147228 | 0.67 | CHRM1 (0.49) | ROCK2P2RX7TRPV1 | |
| SCHEMBL6924475 | 0.67 | PRKCB (0.46) | ROCK2ROCK1CCR2 | |
| SCHEMBL6924480 | 0.67 | PRKCB (0.46) | ROCK2ROCK1CCR2 | |
| SCHEMBL16111141 | 0.66 | DRD4 (0.52) | — | |
| SCHEMBL16111150 | 0.66 | PHGDH (0.45) | ROCK2ROCK1P2RX7 | |
| SCHEMBL3819469 | 0.65 | MAPK8 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024710-A1 | UREA COMPOUNDS ACTIVE AS VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |