Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 16/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 4/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6465310 | 0.84 | CDK7 (0.37) | CDK7CDK9MERTKLRRK2 | |
| SCHEMBL29593105 | 0.79 | IGF1R (0.57) | — | |
| SCHEMBL19690214 | 0.76 | JAK1 (0.33) | CDK7CDK9MERTKLRRK2 | |
| SCHEMBL9957217 | 0.70 | PIK3C3 (0.51) | CDK7CDK9MERTKAXLTYRO3 | |
| SCHEMBL1091018 | 0.67 | TBK1 (0.42) | CHEK1 | |
| SCHEMBL2789966 | 0.67 | MERTK (0.33) | MERTKLRRK2AXLTYRO3PIK3C3 | |
| SCHEMBL12876567 | 0.66 | LRRK2 (0.39) | MERTKLRRK2AXLTYRO3 | |
| SCHEMBL22631476 | 0.66 | MAP4K4 (0.40) | MERTK | |
| Hydrochloric Acid SCHEMBL1521798 | 0.65 | LRRK2 (0.38) | MERTKLRRK2AXLTYRO3 | |
| SCHEMBL12568005 | 0.64 | AURKA (0.44) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |