SCHEMBL6828586

SCHEMBL6828586

O=C(O)c1ccc(F)c(O)c1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALB P02768 1/20 0.53
TSHR P16473 3/20 0.50
CASP1 P29466 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
ALDH1A1 P00352 5/20 0.45
TP53 P04637 1/20 0.45
GRIK1 P39086 2/20 0.44
AKR1C2 P52895 2/20 0.44
AKR1C1 Q04828 2/20 0.44
AKR1C4 P17516 1/20 0.44
AKR1C3 P42330 1/20 0.44
SELL P14151 1/20 0.43
SELP P16109 1/20 0.43
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41
CYP1A2 P05177 1/20 0.41
HSD17B10 Q99714 3/20 0.41
KDM4E B2RXH2 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15878727 0.83 ALB (0.53) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL109128 0.83 TSHR (0.48) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL18529852 0.82 SELL (0.56) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL2579411 0.81 CES2 (0.50) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL31392754 0.81 CES2 (0.50) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL13315472 0.80 ALB (0.65) ALBTSHRCASP1SMN1; SMN2CA1
Hydrochloric Acid SCHEMBL9860906 0.79 CES2 (0.48) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL31455903 0.78 ALB (0.57) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL7880433 0.78 ALB (0.57) ALBTSHRCASP1SMN1; SMN2CA1
SCHEMBL4069345 0.78 DPP4 (0.56) TSHRCASP1SMN1; SMN2CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004073612-A2 ESTROGEN RECEPTOR MODULATORS MERCK & CO. INC. (US) 2004-09-02 WO disclosed